<span data-sheets-value="{&quot;1&quot;:2,&quot;2&quot;:&quot;The power of our transpacific partnerships lies at the heart of our investment and company building strategy. We leverage an extensive global network as well as an \&quot;on-the-ground\&quot;, local presence in both Japan and the United States. This enables us to access differentiated sourcing and early-stage investment opportunities for the creation and development of bespoke new biotech companies on both sides of the Pacific. Through this approach, the team gains insights and perspectives that enable it to maximize therapeutic impact for patients around the world, while generating attractive risk-adjusted returns for investors.&quot;}" data-sheets-userformat="{&quot;2&quot;:14783,&quot;3&quot;:{&quot;1&quot;:0,&quot;3&quot;:1},&quot;4&quot;:{&quot;1&quot;:2,&quot;2&quot;:16703948},&quot;5&quot;:{&quot;1&quot;:[{&quot;1&quot;:2,&quot;2&quot;:0,&quot;5&quot;:{&quot;1&quot;:2,&quot;2&quot;:0}},{&quot;1&quot;:0,&quot;2&quot;:0,&quot;3&quot;:3},{&quot;1&quot;:1,&quot;2&quot;:0,&quot;4&quot;:1}]},&quot;6&quot;:{&quot;1&quot;:[{&quot;1&quot;:2,&quot;2&quot;:0,&quot;5&quot;:{&quot;1&quot;:2,&quot;2&quot;:0}},{&quot;1&quot;:0,&quot;2&quot;:0,&quot;3&quot;:3},{&quot;1&quot;:1,&quot;2&quot;:0,&quot;4&quot;:1}]},&quot;7&quot;:{&quot;1&quot;:[{&quot;1&quot;:2,&quot;2&quot;:0,&quot;5&quot;:{&quot;1&quot;:2,&quot;2&quot;:0}},{&quot;1&quot;:0,&quot;2&quot;:0,&quot;3&quot;:3},{&quot;1&quot;:1,&quot;2&quot;:0,&quot;4&quot;:1}]},&quot;8&quot;:{&quot;1&quot;:[{&quot;1&quot;:2,&quot;2&quot;:0,&quot;5&quot;:{&quot;1&quot;:2,&quot;2&quot;:0}},{&quot;1&quot;:0,&quot;2&quot;:0,&quot;3&quot;:3},{&quot;1&quot;:1,&quot;2&quot;:0,&quot;4&quot;:1}]},&quot;10&quot;:1,&quot;11&quot;:4,&quot;14&quot;:{&quot;1&quot;:3,&quot;3&quot;:1},&quot;15&quot;:&quot;Arial&quot;,&quot;16&quot;:10}">The power of our transpacific partnerships lies at the heart of our investment and company building strategy. We leverage an extensive global network as well as an &#8220;on-the-ground&#8221;, local presence in both Japan and the United States. This enables us to access differentiated sourcing and early-stage investment opportunities for the creation and development of bespoke new biotech companies on both sides of the Pacific. Through this approach, the team gains insights and perspectives that enable it to maximize therapeutic impact for patients around the world, while generating attractive risk-adjusted returns for investors.

Eiji Tanaka

Managing Executive Officer of Mitsubishi Tanabe Pharma Corporation

Mineralys Therapeutics is a private, clinical-stage biopharmaceutical company committed to developing best-in-class, novel therapy for the treatment of hypertension – the leading cause of heart and kidney disease. Mineralys is driven to break the “trial and failure” approach and bring a personalized, targeted approach to the management of hypertension. Through its expertise and focus on the patient, Mineralys aims to change the way hypertension is diagnosed, managed and treated.

A Targeted Approach for the Control of Hypertension

Mineralys - Catalys Pacific

Yoichi Funayama

Senior Executive Officer & General Manager of the Pharmaceutical Business Division of UBE

Kirilys Therapeutics, Inc. (“Kirilys”) was founded by Catalys Pacific as a multi-asset precision oncology company. Kirilys’ lead asset is KRLS-017, a selective and potent Cyclin Dependent Kinase 7 (“CDK7”) inhibitor for multiple oncology indications, in-licensed from UBE. CDK7 has been implicated as a key regulator of both transcriptional addiction and cell cycle dysregulation in tumors and therefore represents an attractive target for therapeutic intervention across a broad range of solid tumors and hematologic malignancies. A best-in-class CDK7 inhibitor could also be optimized using a biomarker strategy to select for patient responders.

Kirilys - Catalys Pacific

Takashi Shibano

Senior Vice President of EA Pharma

Pathalys Pharma, Inc. (“Pathalys”) is a private, late-stage clinical biopharmaceutical company committed to the development of multiple advanced therapeutics that address unmet needs in the management of end-stage kidney disease (“ESKD”). Pathalys’ initial asset is upacicalcet (Pathalys code: PLS240), a novel calcimimetic with the potential to improve the treatment of secondary hyperparathyroidism (“SHPT”), approved in Japan under the brand name UPASITA®. Beyond PLS240, Pathalys continues to identify other high priority needs and potential solutions for patients with chronic kidney disease (“CKD”) and ESKD.

A New Path for Patients with Chronic Kidney Disease

Pathalys - Catalys Pacific

<span data-sheets-value="{&quot;1&quot;:2,&quot;2&quot;:&quot;Improving patient lives worldwide by driving impact and innovation in healthcare and contributing to advancements in life sciences.&quot;}" data-sheets-userformat="{&quot;2&quot;:14783,&quot;3&quot;:{&quot;1&quot;:0,&quot;3&quot;:1},&quot;4&quot;:{&quot;1&quot;:2,&quot;2&quot;:16703948},&quot;5&quot;:{&quot;1&quot;:[{&quot;1&quot;:2,&quot;2&quot;:0,&quot;5&quot;:{&quot;1&quot;:2,&quot;2&quot;:0}},{&quot;1&quot;:0,&quot;2&quot;:0,&quot;3&quot;:3},{&quot;1&quot;:1,&quot;2&quot;:0,&quot;4&quot;:1}]},&quot;6&quot;:{&quot;1&quot;:[{&quot;1&quot;:2,&quot;2&quot;:0,&quot;5&quot;:{&quot;1&quot;:2,&quot;2&quot;:0}},{&quot;1&quot;:0,&quot;2&quot;:0,&quot;3&quot;:3},{&quot;1&quot;:1,&quot;2&quot;:0,&quot;4&quot;:1}]},&quot;7&quot;:{&quot;1&quot;:[{&quot;1&quot;:2,&quot;2&quot;:0,&quot;5&quot;:{&quot;1&quot;:2,&quot;2&quot;:0}},{&quot;1&quot;:0,&quot;2&quot;:0,&quot;3&quot;:3},{&quot;1&quot;:1,&quot;2&quot;:0,&quot;4&quot;:1}]},&quot;8&quot;:{&quot;1&quot;:[{&quot;1&quot;:2,&quot;2&quot;:0,&quot;5&quot;:{&quot;1&quot;:2,&quot;2&quot;:0}},{&quot;1&quot;:0,&quot;2&quot;:0,&quot;3&quot;:3},{&quot;1&quot;:1,&quot;2&quot;:0,&quot;4&quot;:1}]},&quot;10&quot;:1,&quot;11&quot;:4,&quot;14&quot;:{&quot;1&quot;:2,&quot;2&quot;:0},&quot;15&quot;:&quot;Arial&quot;,&quot;16&quot;:10}">Improving patient lives worldwide by driving impact and innovation in healthcare and contributing to advancements in life sciences.

Starting with gratitude for the opportunity to create meaningful healthcare innovations alongside our partners.

Success in entrepreneurship arises from inspiration, yet only is realized through its execution with perseverance, persistence and creativity.

Knowing that true innovation requires an agility and resilience to embrace change, confront challenges, learn from failures, and to pivot accordingly.

We embrace a compass of ethics to better society and science, choosing not to waver in the face of moral crisis.

Framed by successful sails at times, turbulent tides at others.

Our ultimate destination is to better patients’ lives.

Crafted venture backed companies designed to excel in healthcare innovation, no matter where their journey takes them.

Improving patient lives worldwide by driving impact and innovation in healthcare and contributing to advancements in life sciences.

Charter - Catalys Pacific

Catalys Pacific

WE ARE TRANSFORMING LIFE SCIENCES INNOVATION BY CREATING AND INVESTING IN GLOBAL COMPANIES - STARTING IN JAPAN AND THE UNITED STATES​

Catalys Pacific maximizes its profound global network and robust local presence in Japan to propel its mission of improving patient lives. It is an honor to be a part of that mission.”

Transforming Life Sciences Innovation By Creating And Investing In Global Companies

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FDA approval marks the first major innovation to the U.S. Erosive GERD market in over 30 years VOQUEZNA® met the primary endpoints and key secondary superiority endpoints in the pivotal Phase 3 PHALCON-EE trial evaluating VOQUEZNA in comparison to a standard-of-care proton pump inhibitor (PPI)1 Commercial availability of VOQUEZNA expected December 2023 Erosive GERD approval [&hellip;]

Phathom Pharmaceuticals Announces FDA Approval of VOQUEZNA® (vonoprazan) Tablets for the Treatment of Erosive GERD and Relief of Heartburn Associated with Erosive GERD in Adults - Catalys Pacific

Phathom Pharmaceuticals Announces FDA Approval of VOQUEZNA® (vonoprazan) Tablets for the Treatment of Erosive GERD and Relief of Heartburn Associated with Erosive GERD in Adults

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